Coagulation

Disseminated intravascular coagulation and coagulation disorders.

PURPOSE OF REVIEW An update on recent developments in diagnosis and treatment of disseminated intravascular coagulation. RECENT FINDINGS Disseminated intravascular coagulation is defined as a typical disease condition with laboratory findings indicating massive coagulation activation and reduction in procoagulant capacity. Clinical syndromes associated with the condition are consumption coagu...

Blood Coagulation

INTRODUCTION This section covers the means, as far as we now know them, by which components of the blood plasma produce an insoluble protein meshwork, or gel, at a site of blood-vessel damage. The plasma is normally completely fluid, containing all its proteins in soluble form. When the clotting system is activated at a site of blood-vessel damage, a series of proteolytic reactions is set going...

Coagulation Glossary

Coagulation monitoring.

Monitoring hemostasis is now possible by different modalities, of which the point of care devices seem most helpful to the clinician in the operating room. Most of these monitors are being used in the cardiac population, and their significance in other fields remains to be assessed.

Coagulation assays.

Case 1: Mr F, a 75-year-old man with diabetes, was admitted with non–ST-segment-elevation acute coronary syndrome. In addition to other medications, he is receiving 1 mg/kg enoxaparin every 12 hours. He is scheduled for cardiac catheterization later in the afternoon. Earlier this morning, his activated partial thromboplastin time (aPTT) was 30 seconds. How should his anticoagulants be managed? ...